Endocrine Abstracts

E R Simpson, Prince Henry's Institute, Clayton, Victoria, Australia. AbstractDr Evan Simpson is a native of Edinburgh, Scotland. He has had a long interest in the basic biology of estrogen biosynthesis, especially its relationship to breast cancer.His group was the first to clone and characterize the aromatase gene and to show the unique use of tissue-specific promoters to regulate tissue-specif...

Mark E Molitch, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA AbstractMark E. Molitch, MD, is Professor of Medicine and a Member of the Division of Endocrinology, Metabolism and Molecular Medicine at Northwestern University Feinberg School of Medicine, in Chicago, Illinois. Prior to joining the faculty at Northwestern in 1984, Dr. Molitch was an Associate Professor at Tufts University School of...

P E Clayton, Endocrinology and Diabetes Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK AbstractPeter Clayton is Professor of Child Health and Paediatric Endocrinology in the Faculty of Medical and Human Sciences at the University of Manchester. He is an honorary consultant at the Royal Manchester Children’s Hospital and at the Christie Hospital and is the Director of t...

Niels E Skakkebæk, University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark AbstractNeils Skakkebaek graduated from Medical School, Copenhagen (1964) and received basic medical training at the St. Joseph's Hospital, Copenhagen and was also trained in pediatrics and medicine at various hospitals in Copenhagen and was awarded a doctorate in Medical Sciences from the University of Copenha...

Objective: To describe a patient with an unusual course of primary hyperparathyroidism (PHPT) due to parathyroid adenoma in 2004, who developed recurrent hyperparathyroidism due to parathyroid carcinoma in 2010, and a subsequent adenoma in 2011.To our knowledge, this sequential occurrence has not been previously reported in literature.Case: A 57-year old male was operated on for a parathyroid adenoma in the right inferior gland in 2004. He was asymptomat...

Introduction: In 1960, Van Wyk and Grumbach described the association of hypothyroidism and precocious puberty. Hypothyroidism leads to delayed bone age and a reduction in growth rate by reducing the amplitude of GH pulses. When precocious puberty is associated with thyroid hypofunction, estrogen action on the epiphyseal plates reduce this delay. We report the case of a child who developed incomplete puberty and reduced growth rate, caused by primary hypothyroidism.<p clas...

The pseudo-Cushing’s syndrome that accompanies both acute alcohol ingestion and alcohol withdrawal is an important differential diagnosis of hypercortisolism that is poorly understood. Two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) interconvert hormonally active cortisol (F) and inactive cortisone (E). Previously we have shown higher urinary F:E metabolite ratios (a reflection of total body 11βHSD activity) in patients with alcoholic liver disea...

Annexin 1 (ANXA1, lipocortin 1), a Ca2+ and phospholipid binding protein, is a strong candidate mediator of the interplay between the immune and neuroendocrine systems. Within the neuroendocrine system ANXA1 is expressed in abundance by the non-secretory pituitary folliculo-stellate (FS) cells (1), which show characteristics of resident microglia. We have previously reported that IL-6 up-regulates ANXA1 expression in the liver in vivo and in A549 cells (lung epithelial...

A 41 year old man was referred to the endocrine service at St Barts hospital. He had previously had a GP check-up and was found to be hypertensive, this led to him having an ultrasound KUB, an abnormality was detected which resulted in a CT abdomen being performed. The CT abdomen showed a 38×33 mm well defined right adrenal lesion and the patient was referred to endocrinology. Upon review, the patient had been having palpitations for the past year - particularly when stra...

Goal: Study thyroid function in patients with acromegaly. Materials and method: 88 patients with acromegaly, age 54.6±13.2 years, mediana diagnosis acromegaly 4 years, IGF1 528 (265; 701.3 ng/ml, HG 10.4 (3.7; 30.1) μE/ml, only 12 patients had a remission of disease. All patients were taken TSH, fT4, TPO antibodies, revealed anamnesis of thyroid diseases.Results: 19 from 88 patients (21.6%) had hypothyreosis and 2 (2.3%) had subclini...